Joe Biden was again COVID-19 positive after treatment with Paxrovid. It seems to be the case of “rebound”

US President Joe Biden was quarantined after being treated with the antiviral drug Paxrovid and testing positive for COVID-19 a few days after the infection had cleared.

His doctor, Kevin O Connor, said Biden had no recurrence of symptoms and was “quite fine.”

Rather, Dr. O’Connor pointed out that it was a so-called “rebound” case.


What is the timeline?

Mr. Biden first time Positive virus test on July 21 — Within 2 weeks.

he Negative test on Tuesday night.

However, Dr. Biden said Biden continued testing because of “the so-called” rebound “COVID-positive potential observed in a small proportion of patients treated with Paxrovid.”

He continued to test negative on Wednesday, Thursday and Friday.

However, Mr. Biden then returned to isolation. He tested positive again on Saturday morning.

“This actually represents the aggressiveness of the’rebound’,” said Dr. O’Connor.

Biden returned another positive test on Sunday, but he still felt good.


What is a COVID rebound?

The Centers for Disease Control and Prevention (CDC) explains:

“… Recurrence of COVID-19 symptoms, or a new positive virus test after a negative test result.”

There are reports that this is happening 2 to 8 days after recoveryAccording to the CDC Advisory published in late May:

“Based on information from case reports COVID-19 rebound did not represent reinfection With development of resistance to SARS-CoV-2 or Paxlovid. “

These rebound cases It usually resolves in an average of 3 days.

The CDC also said that the short-term recurrence of symptoms could be “a part of the natural history” of the virus that causes COVID-19 in some people, regardless of vaccination status or the presence or absence of Paxlovid. Said.

How common is COVID rebound after Paxlovid?

Estimates are different.

May, Posting to the US Food and Drug Administration (FDA) website Paxlovid clinical trial data show that 1-2% of patients showed one of the following after completing a Paxlovid course of treatment:

  • After testing negative, PCR tested positive for COVID.Also
  • Increased viral load detected by PCR after treatment

In June US studies that have not yet been peer-reviewedFound a rebound rate of 3.53 percent of participants 7 days after Paxrovid treatment and 5.4 percent 30 days after treatment.

The researchers said the group of COVID rebound patients had a “significantly higher” prevalence of the underlying disorder.

What is Paxlovid?

This is an antiviral treatment for COVID-19 approved for use in Australia, but only for those who meet certain criteria.

There are two active ingredients, nilmatrelvir and ritonavir, which are taken as separate tablets.

Patients take twice daily for 5 days.

Who is eligible for antiviral treatment in Australia?

Eligibility criteria for antiviral treatment in Australia Expanded last month..

The treatments are accessible at:

  • People over the age of 70 who test positive for COVID-19, regardless of risk factors, with or without symptoms
  • People over the age of 50 who have two or more risk factors for severe illness
  • Aboriginal or Torres Strait Islanders over 30 years of age with two or more risk factors for severe illness
  • People over the age of 18 who have moderate to severe immunodeficiency, disorders with multiple conditions and / or weakness, or cerebral palsy or Down’s syndrome may also be eligible.
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Joe Biden was again COVID-19 positive after treatment with Paxrovid. It seems to be the case of “rebound”

Source link Joe Biden was again COVID-19 positive after treatment with Paxrovid. It seems to be the case of “rebound”

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