Last year, the artificial intelligence group DeepMind unraveled a mystery that has confused scientists for decades. We stripped off the structure of proteins, which are the components of life. Now, Database Within almost every human protein structure, the company makes resources available online for free for researchers to use.
The key to understanding our basic biological mechanism is its architecture. The chains of amino acids that make up proteins twist and rotate, most disrupting the 3D shape. It is this elaborate form that describes the function of proteins. From enzymes essential for metabolism to antibodies that fight infectious attacks.
Despite years of tedious and costly laboratory work that began in the 1950s, scientists have only deciphered the structure of some of the human proteins. DeepMind’s AI program AlphaFold Almost all 20,000 proteins expressed by humans.. In an independent benchmark test comparing predictions to known structures, the system was able to predict protein shape to a good standard in 95% of the time.
DeepMind, which is affiliated with the European Molecular Biology Laboratory’s European Bioinformatics Laboratory (EMBL-EBI), shows how life lives on an atomic scale by unpacking devices that cause several diseases. I hope it helps to analyze if it works. Develop personalized medicines, “green enzymes” that can create more nutritious crops and break down plastics.
Collaboration with scientists working on projects ranging from diseases that disproportionately affect the poorest parts of the world to research into the biology of viruses that cause antibiotic resistance and Covid has already begun in recent months. I will.
“Applications are really limited only by our imagination, but at a more basic level, the AlphaFold database is about how proteins work and their role in the basic processes of life. We will deepen our understanding, “said Professor Edith Heard, Executive Director. Of EMBL.
“This understanding means better preparation for elucidating the molecular mechanisms of life and accelerating the pursuit of protecting and treating human and global health. Make this tool open access. This will accelerate the power of research and discovery and innovate for scientists around the world. “
AlphaFold’s ability to predict protein structure Fast-paced accuracy It was announced at the “Protein Olympics” held every other year last year. Participants were given amino acid sequences of about 100 proteins and were challenged to elucidate them. AlphaFold not only outperformed other computer programs, but also achieved the same accuracy as the tedious lab-based method.
Professor Ewan Birney, director of EMBL-EBI, said after the results were first announced in November, “I was about to fall out of my chair with excitement and surprise that this long-standing problem with protein folding was resolved. “.
“This dataset is Human genome … And it is this dataset that starts a new science that was not possible before. I’m very excited to start walking that path. “
AI company DeepMind publishes database of life components online | DeepMind
Source link AI company DeepMind publishes database of life components online | DeepMind