Advanced 3D Imaging Model Transforms Selection of IVF Blastocysts

Groundbreaking research presented at the ESHRE 40th Annual Meeting in Amsterdam unveils a revolutionary 3D imaging model designed to discern key features of blastocysts—the early stage of embryo development—linked to successful pregnancies. This innovative approach has the potential to revolutionize current methods for selecting blastocysts, offering new pathways to improve pregnancy rates.

The shape and structure of blastocysts are crucial indicators of pregnancy success in in vitro fertilization (IVF). However, effectively choosing the optimal embryo or blastocyst remains a significant challenge in IVF.

The study focused on women under 40 years old with an endometrial thickness of 7-16mm and no more than one prior embryo transfer failure. Using the EmbryoScope+ device, researchers meticulously captured images of 2,141 cryopreserved single blastocysts.

Advanced technology facilitated the creation of detailed 3D models of these blastocysts, capturing intricate details of their outer layer (trophectoderm) and inner cell mass. These models were then analyzed to uncover new features of blastocysts and determine their correlation with successful pregnancies.

Validation against fluorescence imaging of human blastocysts demonstrated over 90% accuracy. Key metrics such as size, shape, and cellular characteristics of the blastocysts were identified and found to significantly influence pregnancy outcomes. Parameters like overall volume, cavity volume, and surface area were particularly associated with higher pregnancy rates, along with specific features of the inner cell mass and outer layer.

Dr. Huang remarked, “These findings align with clinical outcomes, but were previously unmeasurable. Our study shows that the 3D shape, positioning of the blastocyst’s inner cell mass, and arrangement of surrounding cells are critical indicators of success, which were previously unknown.”

Looking ahead, the research team plans to collaborate across multiple centers to further validate these findings, urging reproductive centers globally to participate. The ultimate aim is to integrate 3D blastocyst evaluation into standard clinical practice, offering renewed hope to individuals undergoing IVF.

Professor Dr. Anis Feki, Chair-Elect of ESHRE, emphasized, “While the new 3D imaging model shows promising potential for enhancing embryo selection in IVF, rigorous validation through additional studies and collaborations is essential. While this method could improve IVF outcomes, its clinical application warrants careful consideration.”

The study’s abstract will be published in Human Reproduction, a premier journal in reproductive medicine.